Socioeconomic measures, orofacial clefts, and conotruncal heart defects in California

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Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial and conotruncal heart defects.

How folate reduces the risks of congenital anomalies is unknown. The authors focused on a gene involved in folate transport-reduced folate carrier-1 gene (RFC1). Using data from a California case-control study (1987-1989 births), the authors investigated whether the risks of orofacial clefts or conotruncal heart defects were influenced by a polymorphism of infant RFC1 or by an interaction betwe...

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Folic acid supplementation and the occurrence of congenital heart defects, orofacial clefts, multiple births, and miscarriage.

Key research findings relative to the question of whether maternal use of folic acid before and during pregnancy reduces the chance that offspring will be born with a congenital heart defect or an orofacial cleft are reviewed in this paper. Observational studies in general support an association between maternal use of multivitamins containing folic acid and a reduction in the occurrence of con...

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Neighborhood Deprivation and Risk of Congenital Heart Defects, Neural Tube Defects and Orofacial Clefts: A Systematic Review and Meta-Analysis

BACKGROUND We conducted this systematic review and meta-analysis to address the open question of a possible association between the socioeconomic level of the neighborhoods in which pregnant women live and the risk of Congenital Heart Defects (CHDs), Neural Tube Defects (NTDs) and OroFacial Clefts (OFCs). METHODS We searched MEDLINE from its inception to December 20th, 2015 for case-control, ...

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Conotruncal Heart Defects: Altered Tissue Morphology and Hemodynamics

1 Biomedical Engineering Program, College of Engineering and Computing, University of South Carolina, Columbia, SC 29208, USA 2 Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29209, USA 3 Department of Pediatrics (Neonatology), Neonatal-Perinatal Research Institute, Duke University Medical Center, Durham, NC 297710, USA 4 Department of Cell...

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Prenatal detection of orofacial clefts

Orofacial clefts are one of the most common congenital anomalies. The incidence is approximately 1 : 500 to 1 : 550 births [1]. The group of orofacial anomalies is heterogeneous. It comprises “typical” orofacial clefts ((cleft lip (CL), cleft lip and cleft palate (CLP) and cleft palate only (CP)) and “atypical” clefts (median, transversal, oblique and other Tessier’s types of facial clefts)[1]....

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ژورنال

عنوان ژورنال: Birth Defects Research Part A: Clinical and Molecular Teratology

سال: 2009

ISSN: 1542-0752,1542-0760

DOI: 10.1002/bdra.20614